Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress

Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress

Natural melanocortins (MCs) have been used in the successful development of drugs with neuroprotective properties. Here, we studied the behavioral effects and molecular genetic mechanisms of two synthetic MC derivatives-ACTH(4–7)PGP (Semax) and ACTH(6–9)PGP under normal and acute restraint stress (A...

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Bibliographic Details
Main Authors: Ivan B. Filippenkov, Vasily V. Stavchansky, Natalya Yu. Glazova, Elena A. Sebentsova, Julia A. Remizova, Liya V. Valieva, Natalia G. Levitskaya, Nikolai F. Myasoedov, Svetlana A. Limborska, Lyudmila V. Dergunova
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
acute restraint stress
melanocortin peptides
anxiety-related behavior
RNA-Seq
gene expression
Online Access:https://www.mdpi.com/1422-0067/22/18/10054

Internet

https://www.mdpi.com/1422-0067/22/18/10054

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