Protective role of matrine in sepsis-associated cardiac dysfunction through regulating the lncRNA PTENP1/miR-106b-5p axis

Protective role of matrine in sepsis-associated cardiac dysfunction through regulating the lncRNA PTENP1/miR-106b-5p axis

Background: Matrine has attractive cardioprotective effects in some diseases. This study aimed to evaluate the therapeutic potential of matrine against cardiac dysfunction induced by sepsis in vivo and in vitro, and further explore the related mechanisms. Methods: Cecal ligation and puncture (CLP) w...

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Bibliographic Details
Main Authors: Yujuan Liu, Lijun Liu, Jun Zhang
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sepsis
Cardiac dysfunction
Matrine
Inflammation
LncRNA PTENP1
miR-106b-5p
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220313056

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http://www.sciencedirect.com/science/article/pii/S0753332220313056

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