HIF-1α regulates IL-1β and IL-17 in sarcoidosis

HIF-1α regulates IL-1β and IL-17 in sarcoidosis

Sarcoidosis is a complex systemic granulomatous disease of unknown etiology characterized by the presence of activated macrophages and Th1/Th17 effector cells. Data mining of our RNA-Seq analysis of CD14+monocytes showed enrichment for metabolic and hypoxia inducible factor (HIF) pathways in sarcoid...

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Bibliographic Details
Main Authors: Jaya Talreja, Harvinder Talwar, Christian Bauerfeld, Lawrence I Grossman, Kezhong Zhang, Paul Tranchida, Lobelia Samavati
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
sarcoidosis
HIF-1α
monocytes
alveolar macrophages
IL-1β
IL-17
Online Access:https://elifesciences.org/articles/44519

Internet

https://elifesciences.org/articles/44519

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