Synthesis of Lasofoxifene, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction

Synthesis of Lasofoxifene, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction

A Lewis acid-mediated three-component coupling reaction was successfully applied for the synthesis of lasofoxifene (1), nafoxidine (2), and their positional isomers, inv-lasofoxifene (3) and inv-nafoxidine (4). In the presence of HfCl4, the desired one-pot coupling reaction among 4-pivaloyloxybenzal...

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Bibliographic Details
Main Authors: Isamu Shiina, Kenya Nakata, Yoshiyuki Sano
Format: Article
Language:English
Published: MDPI AG 2010-09-01
Series:Molecules
Subjects:
three-component coupling reaction
diversity oriented synthesis
lasofoxifene
nafoxidine
inv-lasofoxifene
inv-nafoxidine
Online Access:http://www.mdpi.com/1420-3049/15/10/6773/

Internet

http://www.mdpi.com/1420-3049/15/10/6773/

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