N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

Abstract In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phenotype. This transition endows tumour cells with the capacity to escape from the co...

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Bibliographic Details
Main Authors: Krzysztof Marek Mrozik, Orest William Blaschuk, Chee Man Cheong, Andrew Christopher William Zannettino, Kate Vandyke
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Cancer
Subjects:
N-cadherin
Cancer
Metastasis
Haematological malignancies
Therapeutic target
Online Access:http://link.springer.com/article/10.1186/s12885-018-4845-0

Internet

http://link.springer.com/article/10.1186/s12885-018-4845-0

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