Activation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum

Activation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum

Embryonic stem cells (ESCs) are characterized by the pluripotent capacity to generate all embryonic lineages. Here, we show that ESCs can occupy a spectrum of distinct transcriptional and epigenetic states in response to varied extrinsic conditions. This spectrum broadly corresponds to a development...

Full description

Bibliographic Details
Main Authors: Jamie A. Hackett, Toshihiro Kobayashi, Sabine Dietmann, M. Azim Surani
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Stem Cell Reports
Subjects:
pluripotency
chimeric transcripts
DNA methylation
PGC
transposable element
STAT3
embryonic stem cell
imprints
KLF4
heterogeneity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302217

Internet

http://www.sciencedirect.com/science/article/pii/S2213671117302217

Similar Items