Immune Cell Infiltration of the Primary Tumor, Not PD-L1 Status, Is Associated With Improved Response to Checkpoint Inhibition in Metastatic Melanoma

Immune Cell Infiltration of the Primary Tumor, Not PD-L1 Status, Is Associated With Improved Response to Checkpoint Inhibition in Metastatic Melanoma

Immune checkpoint inhibition has resulted in dramatic improvements in overall and relapse-free survival in patients with metastatic melanoma. The most commonly used immune checkpoint inhibitors are monoclonal antibodies targeting programmed cell death protein 1 and cytotoxic T-lymphocyte-associated...

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Bibliographic Details
Main Authors: Christiane Kümpers, Mladen Jokic, Ozan Haase, Anne Offermann, Wenzel Vogel, Victoria Grätz, Ewan A. Langan, Sven Perner, Patrick Terheyden
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Medicine
Subjects:
melanoma
PD-L1
immunoscore
checkpoint inhibition
lymphocyte
metastases
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00027/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2019.00027/full

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