Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer

Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer

Abstract Background Synthetic lethal interactions (SLIs) that occur between gene pairs are exploited for cancer therapeutics. Studies in the model eukaryote yeast have identified ~ 550,000 negative genetic interactions that have been extensively studied, leading to characterization of novel pathways...

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Bibliographic Details
Main Authors: Morgan W. B. Kirzinger, Frederick S. Vizeacoumar, Bjorn Haave, Cristina Gonzalez-Lopez, Keith Bonham, Anthony Kusalik, Franco J. Vizeacoumar
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Medical Genomics
Subjects:
Synthetic lethality
Breast cancer
Gene expression
Genetic interaction network
Online Access:http://link.springer.com/article/10.1186/s12920-019-0554-z

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http://link.springer.com/article/10.1186/s12920-019-0554-z

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