Piper sarmentosum Promotes Endothelial Nitric Oxide Production by Reducing Asymmetric Dimethylarginine in Tumor Necrosis Factor-α-Induced Human Umbilical Vein Endothelial Cells

Piper sarmentosum Promotes Endothelial Nitric Oxide Production by Reducing Asymmetric Dimethylarginine in Tumor Necrosis Factor-α-Induced Human Umbilical Vein Endothelial Cells

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase (eNOS). ADMA is degraded by dimethylarginine dimethylaminohydrolase (DDAH). Elevated levels of ADMA lead to reduction in nitric oxide (NO) production, which is linked to endothelial dysfunction and ath...

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Bibliographic Details
Main Authors: Uma Mahgesswary Sundar, Azizah Ugusman, Hui Kien Chua, Jalifah Latip, Amilia Aminuddin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
Piper sarmentosum
asymmetric dimethylarginine
dimethylarginine dimethylaminohydrolase
human umbilical vein endothelial cells
tumor necrosis factor-α
endothelial dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01033/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01033/full

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