Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

Abstract Background Identifying selective kinase inhibitors remains a major challenge. The design of bivalent inhibitors provides a rational strategy for accessing potent and selective inhibitors. While bivalent kinase inhibitors have been successfully designed, no comprehensive assessment of affini...

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Bibliographic Details
Main Authors: Margaret L. Wong, Jason Murphy, Edmund Harrington, Carrie M. Gower, Rishi K. Jain, Markus Schirle, Jason R. Thomas
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Proteome Science
Subjects:
Chemical proteomics
Isobaric Tagging
Kinase profiling
Bivalent kinase inhibitor
SNAPtag
Structure activity relationship
Online Access:http://link.springer.com/article/10.1186/s12953-017-0125-1

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http://link.springer.com/article/10.1186/s12953-017-0125-1

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