Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular Carcinoma

Background: Metronomic chemotherapy involves frequent, regular administration of cytotoxic drugs at nontoxic doses, usually without prolonged breaks. We investigated the therapeutic efficacies of metronomic S-1, an oral 5-fluorouracil prodrug, and vandetanib, an epidermal growth factor receptor and...

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Main Authors: Hideki Iwamoto, Takuji Torimura, Toru Nakamura, Osamu Hashimoto, Kinya Inoue, Junichi Kurogi, Takashi Niizeki, Reiichiro Kuwahara, Mitsuhiko Abe, Hiromori Koga, Hirohisa Yano, Robert S. Kerbel, Takato Ueno, Michio Sata
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800679