Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity

Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity

The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches.

Bibliographic Details
Main Authors: Anukul T. Shenoy, Carolina Lyon De Ana, Emad I. Arafa, Isabelle Salwig, Kimberly A. Barker, Filiz T. Korkmaz, Aditya Ramanujan, Neelou S. Etesami, Alicia M. Soucy, Ian M. C. Martin, Brian R. Tilton, Anne Hinds, Wesley N. Goltry, Hasmeena Kathuria, Thomas Braun, Matthew R. Jones, Lee J. Quinton, Anna C. Belkina, Joseph P. Mizgerd
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26045-w

Internet

https://doi.org/10.1038/s41467-021-26045-w

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