Glucose regulates rat beta cell number through age-dependent effects on beta cell survival and proliferation.

BACKGROUND: Glucose effects on beta cell survival and DNA-synthesis suggest a role as regulator of beta cell mass but data on beta cell numbers are lacking. We examined outcome of these influences on the number of beta cells isolated at different growth stages in their population. METHODS: Beta cell...

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Bibliographic Details
Main Authors: Zerihun Assefa, Astrid Lavens, Christophe Steyaert, Geert Stangé, Geert A Martens, Zhidong Ling, Karine Hellemans, Daniel Pipeleers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3887027?pdf=render