Preexisting heart failure with reduced ejection fraction attenuates renal fibrosis after ischemia reperfusion via sympathetic activation

Preexisting heart failure with reduced ejection fraction attenuates renal fibrosis after ischemia reperfusion via sympathetic activation

Abstract Although chronic heart failure is clinically associated with acute kidney injury (AKI), the precise mechanism that connects kidney and heart remains unknown. Here, we elucidate the effect of pre-existing heart failure with reduced ejection fraction (HFrEF) on kidney via sympathetic activity...

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Bibliographic Details
Main Authors: Ryo Matsuura, Tetsushi Yamashita, Naoki Hayase, Yoshifumi Hamasaki, Eisei Noiri, Genri Numata, Eiki Takimoto, Masaomi Nangaku, Kent Doi
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94617-3

Internet

https://doi.org/10.1038/s41598-021-94617-3

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