IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors

IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors

Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of depression. Interleukin-6 is upregulated in depressed patients and dowregulated by antidepressants. It is, however, unknown whether IL-6 is involved in the pathogenesis of depression.We subjected IL-6-deficient mice...

Full description

Bibliographic Details
Main Authors: Sabine Chourbaji, Alexandre Urani, Ioana Inta, Carles Sanchis-Segura, Christiane Brandwein, Mathias Zink, Markus Schwaninger, Peter Gass
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Subjects:
Cytokines
Depression
Anxiety
Animal model
IL-6
Knockout mice
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610600115X

Internet

http://www.sciencedirect.com/science/article/pii/S096999610600115X

Similar Items