Adipose-Derived Stem Cells Promote Bone Coupling in Bisphosphonate-Related Osteonecrosis of the Jaw by TGF-β1

Adipose-Derived Stem Cells Promote Bone Coupling in Bisphosphonate-Related Osteonecrosis of the Jaw by TGF-β1

This study aimed to investigate molecularly targeted therapy to revive bone remodeling and prevent BRONJ by local adipose-derived stem cells (ADSCs) transplantation. Clinical samples of BRONJ and healthy jawbones were used to examine the bone coupling-related cells and TGF-β1 expression. Bone coupli...

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Bibliographic Details
Main Authors: Xian Dong, Linhai He, Xiaolong Zang, Yang He, Jingang An, Baoping Wu, Xinhua Liu, Hongsen Bi, Yi Zhang, E. Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
adipose-derived mesenchymal stem cells
transforming growth factor beta1
zoledronic acid
bone remodeling
osteoclasts
bisphosphonate-related osteonecrosis of the jaw (BRONJ)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.639590/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.639590/full

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