Increased Transglutaminase 2 Expression and Activity in Rodent Models of Obesity/Metabolic Syndrome and Aging

Diastolic dysfunction of the heart and decreased compliance of the vasculature and lungs (i.e., increased organ tissue stiffness) are known features of obesity and the metabolic syndrome. Similarly, cardiac diastolic dysfunction is associated with aging. Elevation of the enzyme transglutaminase 2 (T...

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Bibliographic Details
Main Authors: Krishna C. Penumatsa, Ines Falcão-Pires, Sara Leite, Adelino Leite-Moreira, Chinmayee D. Bhedi, Sabina Nasirova, Jing Ma, Roy L. Sutliff, Barry L. Fanburg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.560019/full