Complement C4A Regulates Autoreactive B Cells in Murine Lupus

Complement C4A Regulates Autoreactive B Cells in Murine Lupus

Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact. Despite being 99% homologous, genetic studies identified C4A as more protect...

Full description

Bibliographic Details
Main Authors: Léa Simoni, Jessy Presumey, Cees E. van der Poel, Carlos Castrillon, Sarah E. Chang, Paul J. Utz, Michael C. Carroll
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
Complement C4
SLE
B cell tolerance
Murine model
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031319X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472031319X

Similar Items