Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells

Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example of a sterile injury is myocardial infarction...

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Bibliographic Details
Main Authors: Katrien Van der Borght, Charlotte L. Scott, Veronika Nindl, Ann Bouché, Liesbet Martens, Dorine Sichien, Justine Van Moorleghem, Manon Vanheerswynghels, Sofie De Prijck, Yvan Saeys, Burkhard Ludewig, Thierry Gillebert, Martin Guilliams, Peter Carmeliet, Bart N. Lambrecht
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
dendritic cell
heart
tolerance
autoimmunity
myocardial infarction
tissue necrosis
IRF4
IRF8
cardiac myosin
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302991

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http://www.sciencedirect.com/science/article/pii/S2211124717302991

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