The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.

The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.

TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF. We demonstrate that translation of the TNF-precur...

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Bibliographic Details
Main Authors: Christopher Tiedje, Natalia Ronkina, Mohammad Tehrani, Sonam Dhamija, Kathrin Laass, Helmut Holtmann, Alexey Kotlyarov, Matthias Gaestel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3459988?pdf=render

Internet

http://europepmc.org/articles/PMC3459988?pdf=render

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