An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis

An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis

N-Methyl-D-aspartate (NMDA) receptors (NMDARs) are among the most important excitatory neurotransmitter receptors in the human brain. Autoantibodies to the human NMDAR cause the most frequent form of autoimmune encephalitis involving autoantibody-mediated receptor cross-linking and subsequent intern...

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Bibliographic Details
Main Authors: Elsie Amedonu, Christoph Brenker, Sumanta Barman, Julian A. Schreiber, Sebastian Becker, Stefan Peischard, Nathalie Strutz-Seebohm, Christine Strippel, Andre Dik, Hans-Peter Hartung, Thomas Budde, Heinz Wiendl, Timo Strünker, Bernhard Wünsch, Norbert Goebels, Sven G. Meuth, Guiscard Seebohm, Nico Melzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Neurology
Subjects:
autoimmune encephalitis
N-Methyl-D-aspartate receptors
cross-linking
endocytosis
vesicular trafficking
exocytosis
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00178/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.00178/full

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