Interleukin-6, -8, and TGF-β Secreted from Mesenchymal Stem Cells Show Functional Role in Reduction of Telomerase Activity of Leukemia Cell Via Wnt5a/β-Catenin and P53 Pathways

Interleukin-6, -8, and TGF-β Secreted from Mesenchymal Stem Cells Show Functional Role in Reduction of Telomerase Activity of Leukemia Cell Via Wnt5a/β-Catenin and P53 Pathways

Purpose: The effect of mesenchymal stem cells (MSCs) on the immortality features of malignant cells, such as hematologic cancerous cells, are controversial, and the associated mechanisms are yet to be well understood. The aim of the present study was to investigate the in vitro effect of bone marrow...

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Bibliographic Details
Main Authors: Ezzatollah Fathi, Behnaz Valipour, Zohreh Sanaat, Hojjatollah Nozad Charoudeh, Raheleh Farahzadi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2020-02-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
mesenchymal stem cells
telomere length
telomerase activity
cytokines
wnt5a/β-catenin
p53 signaling pathways
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-27854

Internet

https://apb.tbzmed.ac.ir/PDF/apb-27854

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