Carvedilol, an Adrenergic Blocker, Suppresses Melanin Synthesis by Inhibiting the cAMP/CREB Signaling Pathway in Human Melanocytes and Ex Vivo Human Skin Culture

Carvedilol, an Adrenergic Blocker, Suppresses Melanin Synthesis by Inhibiting the cAMP/CREB Signaling Pathway in Human Melanocytes and Ex Vivo Human Skin Culture

Catecholamines function via G protein-coupled receptors, triggering an increase in intracellular levels of 3′,5′-cyclic adenosine monophosphate (cAMP) in various cells. Catecholamine biosynthesis and the β-adrenergic receptor exist in melanocytes; thus, catecholamines may play critical roles in skin...

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Bibliographic Details
Main Authors: Myoung Eun Choi, Hanju Yoo, Ha-Ri Lee, Ik Joon Moon, Woo Jin Lee, Youngsup Song, Sung Eun Chang
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
carvedilol
adrenergic blocker
melanin synthesis
cAMP/CREB signaling
Online Access:https://www.mdpi.com/1422-0067/21/22/8796

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https://www.mdpi.com/1422-0067/21/22/8796

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