CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

The integration of exogenous DNA into the genome using CRISPR–Cas9 often presents a challenge to researchers. Here the authors fuse CtIP to Cas9 to stimulate recombination at target loci.

Bibliographic Details
Main Authors: M. Charpentier, A. H. Y. Khedher, S. Menoret, A. Brion, K. Lamribet, E. Dardillac, C. Boix, L. Perrouault, L. Tesson, S. Geny, A. De Cian, J. M. Itier, I. Anegon, B. Lopez, C. Giovannangeli, J. P. Concordet
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03475-7

Internet

https://doi.org/10.1038/s41467-018-03475-7

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