Dynamic Intracellular Metabolic Cell Signaling Profiles During Ag-Dependent B-Cell Differentiation

Dynamic Intracellular Metabolic Cell Signaling Profiles During Ag-Dependent B-Cell Differentiation

Human B-cell differentiation has been extensively investigated on genomic and transcriptomic grounds; however, no studies have accomplished so far detailed analysis of antigen-dependent maturation-associated human B-cell populations from a proteomic perspective. Here, we investigate for the first ti...

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Main Authors: Paula Díez, Martín Pérez-Andrés, Martin Bøgsted, Mikel Azkargorta, Rodrigo García-Valiente, Rosa M. Dégano, Elena Blanco, Sheila Mateos-Gomez, Paloma Bárcena, Santiago Santa Cruz, Rafael Góngora, Félix Elortza, Alicia Landeira-Viñuela, Pablo Juanes-Velasco, Victor Segura, Raúl Manzano-Román, Julia Almeida, Karen Dybkaer, Alberto Orfao, Manuel Fuentes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
B-cell differentiation
naive B cell
centroblast
centrocyte
memory B cell
quantitative proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.637832/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.637832/full

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