DAGLα Inhibition as a Non-invasive and Translational Model of Episodic Headache

DAGLα Inhibition as a Non-invasive and Translational Model of Episodic Headache

Recent findings suggested that Clinical Endocannabinoid Deficiency underlies the pathophysiology of pain disorders, including migraine and headache. In models of medication overuse headache induced by sustained administration of sumatriptan or morphine, 2-AG levels were selectively depleted in the p...

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Bibliographic Details
Main Authors: Aidan Levine, Erika Liktor-Busa, Kelly L. Karlage, Luigi Giancotti, Daniela Salvemini, Todd W. Vanderah, Tally M. Largent-Milnes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
headache
migraine
translational models
endocannabinoid system
DAGL
clinical endocannabinoid deficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.615028/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.615028/full

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