Tofacitinib Represses the Janus Kinase-Signal Transducer and Activators of Transcription Signalling Pathway in Keratinocytes

Tofacitinib is a Janus kinase (JAK) inhibitor, which has shown efficacy in treating psoriasis. The mode of action of tofacitinib is not completely understood but it has been thought to be mediated by the inhibition of CD4+ T-cell activation. Here, we investigated whether the molecular targets of tof...

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Bibliographic Details
Main Authors: Ankit Srivastava, Mona Ståhle, Andor Pivarcsi, Enikö Sonkoly
Format: Article
Language:English
Published: Society for Publication of Acta Dermato-Venereologica 2018-05-01
Series:Acta Dermato-Venereologica
Subjects:
Online Access: https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2960