Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells

Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells

T and B cell compartmentalization is a hallmark of secondary lymphoid organs and is maintained by chemokine-expressing stromal cells. How this stromal cell network initially develops and differentiates into two distinct subsets is poorly known, especially for the splenic white pulp (WP). Here, we sh...

Full description

Bibliographic Details
Main Authors: Karin Schaeuble, Mirjam R. Britschgi, Leo Scarpellino, Stéphanie Favre, Ying Xu, Ekaterina Koroleva, Tonje K.A. Lissandrin, Alexander Link, Mehrdad Matloubian, Carl F. Ware, Sergei A. Nedospasov, Alexei V. Tumanov, Jason G. Cyster, Sanjiv A. Luther
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
PALS
lymphotoxin
fibroblast heterogeneity
stroma
chemokines
CXCL13
CCR7
lymphocytes
LTi cells
ILC3
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315991

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717315991

Similar Items