Increased cell-cell coupling increases infarct size and does not decrease incidence of ventricular tachycardia in mice

Increased cell-cell coupling increases infarct size and does not decrease incidence of ventricular tachycardia in mice

Increasing Connexin43 (Cx43) gap junctional conductance as a means to improve cardiac conduction has been proposed as a novel antiarrhythmic modality. Yet, transmission of molecules via gap junctions may be associated with increased infarct size. To determine whether maintaining open gap junction...

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Bibliographic Details
Main Authors: Kevin A Prestia, Eugene A Sosunov, Evgeny P Anyukhovsky, Elena eDolmatova, Caitlin W Kelly, Peter R Brink, Richard B Robinson, Michael R Rosen, Heather S. eDuffy
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-01-01
Series:Frontiers in Physiology
Subjects:
Coronary Occlusion
Myocardial Infarction
connexin43
Antiarrhythmic therapy
Connexin32
Infarct size
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00001/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00001/full

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