A Bi-Exponential Repair Algorithm for Radiation-Induced Double-Strand Breaks: Application to Simulation of Chromosome Aberrations

Background: Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., <i>N(t) = N<sub>1</sub>exp(&#8722;t/...

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Bibliographic Details
Main Authors: Ianik Plante, Tony Slaba, Zarana Shavers, Megumi Hada
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/10/11/936