Inhibition of AKT2 Enhances Sensitivity to Gemcitabine via Regulating PUMA and NF-κB Signaling Pathway in Human Pancreatic Ductal Adenocarcinoma

Inhibition of AKT2 Enhances Sensitivity to Gemcitabine via Regulating PUMA and NF-κB Signaling Pathway in Human Pancreatic Ductal Adenocarcinoma

Invasion, metastasis and resistance to conventional chemotherapeutic agents are obstacles to successful treatment of pancreatic cancer, and a better understanding of the molecular basis of this malignancy may lead to improved therapeutics. In the present study, we investigated whether AKT2 silencing...

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Bibliographic Details
Main Authors: Kejun Zhang, Dianliang Zhang, Jun Liang, Dong Chen, Xuelong Jiao, Min Niu
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic cancer
gemcitabine
AKT
NF-κB
PUMA
Online Access:http://www.mdpi.com/1422-0067/13/1/1186/

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http://www.mdpi.com/1422-0067/13/1/1186/

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