PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA

PWP1 is a chromatin binding protein with an important role in animal growth control downstream of mTOR-mediated nutrient sensing. PWP1 has been shown to control tissue growth by promoting the transcription of 5.8S, 18S and 28S ribosomal RNAs (rRNAs) by RNA polymerase I (Pol I). Concomitantly with Po...

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Bibliographic Details
Main Authors: Ying Liu, Rita Cerejeira Matos, Tapio I. Heino, Ville Hietakangas
Format: Article
Language:English
Published: The Company of Biologists 2018-11-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/7/11/bio037911