Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

Sterol 14α-demethylase (CYP51) that catalyzes the removal of the 14α-methyl group from the sterol nucleus is an essential enzyme in sterol biosynthesis, a primary target for clinical and agricultural antifungal azoles and an emerging target for antitrypanosomal chemotherapy. Here, we present the cry...

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Bibliographic Details
Main Authors: Tatiana Y. Hargrove, Zdzislaw Wawrzak, Jialin Liu, Michael R. Waterman, W. David Nes, Galina I. Lepesheva
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Journal of Lipid Research
Subjects:
sterol biosynthesis
sterol biosynthetic enzymes
inhibition
suicide substrates
crystal structure
cytochrome P450
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520407898

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http://www.sciencedirect.com/science/article/pii/S0022227520407898

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