Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues

Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues

We tested whether sterol-regulatory element binding proteins (SREBPs) mediate sterol-regulated transactivation of the Niemann-Pick C-1 (NPC-1) gene. Loading granulosa cells with 22- or 25-hydroxycholesterol decreased NPC-1 mRNA, whereas culturing in cholesterol-depleted medium or inhibition of chole...

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Bibliographic Details
Main Authors: Nicolas Gévry, Kristina Schoonjans, Fréderic Guay, Bruce D. Murphy
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Journal of Lipid Research
Subjects:
sterol regulatory element binding protein
gene transcription
cholesterol trafficking
granulosa cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520425891

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http://www.sciencedirect.com/science/article/pii/S0022227520425891

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