Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury

Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury

Abstract RIP1 kinase-mediated inflammatory and cell death pathways have been implicated in the pathology of acute and chronic disorders of the nervous system. Here, we describe a novel animal model of RIP1 kinase deficiency, generated by knock-in of the kinase-inactivating RIP1(D138N) mutation in ra...

Full description

Bibliographic Details
Main Authors: Kimberly Stark, Tatiana Goncharov, Eugene Varfolomeev, Luke Xie, Hai Ngu, Ivan Peng, Keith R. Anderson, Erik Verschueren, Meena Choi, Donald S. Kirkpatrick, Amy Easton, Joshua D. Webster, Brent S. McKenzie, Domagoj Vucic, Baris Bingol
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03651-6

Internet

https://doi.org/10.1038/s41419-021-03651-6

Similar Items