MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy

MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy

Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer’s disease (AD) development as its overexpression is directly linked to increased tau phosphorylation. MARK4 is a potential drug target of AD and is thus its structural features are employed in the development of new therape...

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Bibliographic Details
Main Authors: Anas Shamsi, Saleha Anwar, Taj Mohammad, Mohamed F. Alajmi, Afzal Hussain, Md. Tabish Rehman, Gulam Mustafa Hasan, Asimul Islam, Md. Imtaiyaz Hassan
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Biomolecules
Subjects:
acetylcholinesterase inhibitors
drug design and discovery
kinase inhibitors
molecular modeling and docking
isothermal titration calorimetry
Alzheimer’s disease
Online Access:https://www.mdpi.com/2218-273X/10/5/789

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https://www.mdpi.com/2218-273X/10/5/789

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