Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin

Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin

Familial hypertrophic cardiomyopathy (FHC) is a disease of cardiac sarcomeres. To identify molecular mechanisms underlying FHC pathology, functional and structural differences in three FHC-related mutations in recombinant α-Tm (V95A, D175N, and E180G) were characterized using both conventional and...

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Bibliographic Details
Main Authors: Fang Wang, Nicolas M. Brunet, Justin R. Grubich, Ewa A. Bienkiewicz, Thomas M. Asbury, Lisa A. Compton, Goran Mihajlović, Victor F. Miller, P. Bryant Chase
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2011/435271

Internet

http://dx.doi.org/10.1155/2011/435271

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