Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome

Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome

Background: Both supraphysiological and subphysiological testosterone levels are associated with increased cardiovascular risk. Testosterone consumption at supraphysiological doses has been linked to increased blood pressure, left ventricular hypertrophy, vascular dysfunction, and increased levels o...

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Bibliographic Details
Main Authors: Juliano Vilela Alves, Rafael Menezes da Costa, Camila André Pereira, Aline Garcia Fedoce, Carlos Alberto Aguiar Silva, Fernando Silva Carneiro, Núbia Souza Lobato, Rita C. Tostes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
testosterone
androgen receptor
NLRP3 inflammasome
reactive oxygen species
vascular dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01647/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01647/full

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