Abundance of HPV L1 Intra-Genotype Variants With Capsid Epitopic Modifications Found Within Low- and High-Grade Pap Smears With Potential Implications for Vaccinology

Abundance of HPV L1 Intra-Genotype Variants With Capsid Epitopic Modifications Found Within Low- and High-Grade Pap Smears With Potential Implications for Vaccinology

Background: The aim of this study was to explore the Human Papillomavirus (HPV) genotype composition and intra-genotype variants within individual samples of low- and high-grade cervical cytology by deep sequencing. Clinical, cytological, sequencing, and functional/structural data were forged into a...

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Bibliographic Details
Main Authors: Jane Shen-Gunther, Hong Cai, Hao Zhang, Yufeng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
human papillomavirus
HPV genotyping
HSIL
late major capsid protein L1
metagenome
next generation sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00489/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00489/full

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