Using Colistin as a Trojan Horse: Inactivation of Gram-Negative Bacteria with Chlorophyllin

Using Colistin as a Trojan Horse: Inactivation of Gram-Negative Bacteria with Chlorophyllin

Colistin (polymyxin E) is a membrane-destabilizing antibiotic used against Gram-negative bacteria. We have recently reported that the outer membrane prevents the uptake of antibacterial chlorophyllin into Gram-negative cells. In this study, we used sub-toxic concentrations of colistin to weaken this...

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Bibliographic Details
Main Authors: Peter Richter, Marcus Krüger, Binod Prasad, Susanne Gastiger, Mona Bodenschatz, Florian Wieder, Andreas Burkovski, Walter Geißdörfer, Michael Lebert, Sebastian M. Strauch
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Antibiotics
Subjects:
chlorophyll
bacteria
photosensitization
combination therapy
antibiotic resistance
<i>mcr-1</i>
Online Access:https://www.mdpi.com/2079-6382/8/4/158

Internet

https://www.mdpi.com/2079-6382/8/4/158

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