Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone

Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone

Sauchinone, an active lignan isolated from the aerial parts of Saururus chinensis (Saururaceae), exhibits anti-inflammatory, anti-obesity, anti-hyperglycemic, and anti-hepatic steatosis effects. As herb–drug interaction (HDI) through cytochrome P450s (CYPs)-mediated metabolism limits clinical applic...

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Bibliographic Details
Main Authors: Eun Chae Gong, Satya Chea, Anand Balupuri, Nam Sook Kang, Young-Won Chin, Young Hee Choi
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
sauchinone
Saururus chinensis
CYP450
metabolic inhibition
herb-drug interaction
human liver microsome
docking
Online Access:http://www.mdpi.com/1420-3049/23/3/555

Internet

http://www.mdpi.com/1420-3049/23/3/555

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