Dimethyl Fumarate Suppresses Demyelination and Axonal Loss through Reduction in Pro-Inflammatory Macrophage-Induced Reactive Astrocytes and Complement C3 Deposition

Dimethyl Fumarate Suppresses Demyelination and Axonal Loss through Reduction in Pro-Inflammatory Macrophage-Induced Reactive Astrocytes and Complement C3 Deposition

Dimethyl fumarate (DMF) is an oral agent for relapsing-remitting multiple sclerosis (RRMS). In this study, we investigated the therapeutic mechanism of DMF using experimental autoimmune encephalomyelitis (EAE). DMF treatment decreased the proliferation of T cells and the production of IL-17A and GM-...

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Bibliographic Details
Main Authors: Sudhir K. Yadav, Naoko Ito, Devika Soin, Kouichi Ito, Suhayl Dhib-Jalbut
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Journal of Clinical Medicine
Subjects:
dimethyl fumarate
experimental autoimmune encephalomyelitis
iNOS<sup>+ </sup>macrophage
Ym1<sup>+</sup> macrophages
reactive C3<sup>+</sup> astrocytes
complement C3
Online Access:https://www.mdpi.com/2077-0383/10/4/857

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https://www.mdpi.com/2077-0383/10/4/857

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