Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing

Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing

Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast cancer. It benefits nearly 75% of patients with estrogen receptor (ER)-positive breast cancer that receive this drug. Its effectiveness is mainly attributed to its capacity to function as an ER antagonist,...

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Bibliographic Details
Main Authors: Milad Rouhimoghadam, Shahrokh Safarian, Jason S. Carroll, Nader Sheibani, Gholamreza Bidkhori
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
tamoxifen
GPR30
ODE modeling
RNA sequencing
apoptosis
MCF-7
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00907/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00907/full

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