A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

C19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.

Bibliographic Details
Main Authors:	Junlin Wang, Yanan Zhang, Huanhuan Liu, Yong Shang, Linjun Zhou, Penglin Wei, Wen-Bing Yin, Zixin Deng, Xudong Qu, Qianghui Zhou
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11344-0

id	doaj-c3b8f0efe137499a839f5836ca824b91
record_format	Article
spelling	doaj-c3b8f0efe137499a839f5836ca824b912021-05-11T12:04:20ZengNature Publishing GroupNature Communications2041-17232019-07-011011910.1038/s41467-019-11344-0A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroidsJunlin Wang0Yanan Zhang1Huanhuan Liu2Yong Shang3Linjun Zhou4Penglin Wei5Wen-Bing Yin6Zixin Deng7Xudong Qu8Qianghui Zhou9Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Institute for Advanced Studies, College of Chemistry and Molecular Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversitySauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Institute for Advanced Studies, College of Chemistry and Molecular Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of SciencesState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of SciencesKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversitySauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Institute for Advanced Studies, College of Chemistry and Molecular Sciences, Wuhan UniversityC19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.https://doi.org/10.1038/s41467-019-11344-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Junlin Wang Yanan Zhang Huanhuan Liu Yong Shang Linjun Zhou Penglin Wei Wen-Bing Yin Zixin Deng Xudong Qu Qianghui Zhou
spellingShingle	Junlin Wang Yanan Zhang Huanhuan Liu Yong Shang Linjun Zhou Penglin Wei Wen-Bing Yin Zixin Deng Xudong Qu Qianghui Zhou A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids Nature Communications
author_facet	Junlin Wang Yanan Zhang Huanhuan Liu Yong Shang Linjun Zhou Penglin Wei Wen-Bing Yin Zixin Deng Xudong Qu Qianghui Zhou
author_sort	Junlin Wang
title	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_short	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_full	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_fullStr	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_full_unstemmed	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_sort	biocatalytic hydroxylation-enabled unified approach to c19-hydroxylated steroids
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	C19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.
url	https://doi.org/10.1038/s41467-019-11344-0
work_keys_str_mv	AT junlinwang abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT yananzhang abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT huanhuanliu abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT yongshang abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT linjunzhou abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT penglinwei abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT wenbingyin abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT zixindeng abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT xudongqu abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT qianghuizhou abiocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT junlinwang biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT yananzhang biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT huanhuanliu biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT yongshang biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT linjunzhou biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT penglinwei biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT wenbingyin biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT zixindeng biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT xudongqu biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids AT qianghuizhou biocatalytichydroxylationenabledunifiedapproachtoc19hydroxylatedsteroids
_version_	1721445531534753792

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

Similar Items