A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

C19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.

Bibliographic Details
Main Authors: Junlin Wang, Yanan Zhang, Huanhuan Liu, Yong Shang, Linjun Zhou, Penglin Wei, Wen-Bing Yin, Zixin Deng, Xudong Qu, Qianghui Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11344-0

Internet

https://doi.org/10.1038/s41467-019-11344-0

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