Large T antigen-specific cytotoxic T cells protect against dendritic cell tumors through perforin-mediated mechanisms independent of CD4 T cell help

Large T antigen-specific cytotoxic T cells protect against dendritic cell tumors through perforin-mediated mechanisms independent of CD4 T cell help

Our newly generated murine tumor (MuTu) dendritic cell (DC) lines, generated from tumors developing in transgenic mice expressing the SV40 large T antigen and GFP under the DC specific promoter CD11c, reproduce the phenotypic and functional properties of splenic wild type CD8α+ conventional DCs. The...

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Bibliographic Details
Main Authors: Anais eDuval, Silvia Asuncion Fuertes Marraco, Dominik eSchwitter, Line eLeuenberger, Hans eAcha-Orbea
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Immunology
Subjects:
Perforin
dendritic cell
tolerance
CD4 T cells
CD8 T cell
large T antigen
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00338/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00338/full

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