A Knockin Reporter Allows Purification and Characterization of mDA Neurons from Heterogeneous Populations

A Knockin Reporter Allows Purification and Characterization of mDA Neurons from Heterogeneous Populations

Generation of midbrain dopaminergic (mDA) neurons from human pluripotent stem cells provides a platform for inquiry into basic and translational studies of Parkinson’s disease (PD). However, heterogeneity in differentiation in vitro makes it difficult to identify mDA neurons in culture or in vivo fo...

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Bibliographic Details
Main Authors: Ninuo Xia, Fang Fang, Pengbo Zhang, Jun Cui, Chhavy Tep-Cullison, Tim Hamerley, Hyun Joo Lee, Theo Palmer, Brian Bothner, Jin Hyung Lee, Renee Reijo Pera
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
dopaminergic neurons
tyrosine hydroxylase
reporter
stem cell
gene editing
transcriptome profiling
enhancers
5-hydroxymethylcytosine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302048

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http://www.sciencedirect.com/science/article/pii/S2211124717302048

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