A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance

Broad-spectrum drug resistance is a major obstacle in cancer treatment, which is often caused by overexpression of ABC transporters the levels of which vary between individuals due to single-nucleotide polymorphisms (SNPs) in their genes. In the present study, we focused on the human ABC transporter...

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Bibliographic Details
Main Authors: Megumi Tsukamoto, Miho Yamashita, Tsuyoshi Nishi, Hiroshi Nakagawa
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
SNP
Online Access:http://www.mdpi.com/2073-4409/8/1/39