BRCA1 mutation influences progesterone response in human benign mammary organoids

BRCA1 mutation influences progesterone response in human benign mammary organoids

Abstract Background Women, who carry a germline BRCA1 gene mutation, have a markedly increased risk of developing breast cancer during their lifetime. While BRCA1 carriers frequently develop triple-negative, basal-like, aggressive breast tumors, hormone signaling is important in the genesis of BRCA1...

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Bibliographic Details
Main Authors: Batzaya Davaadelger, Mi-Ran Choi, Hari Singhal, Susan E. Clare, Seema A. Khan, J. Julie Kim
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Breast Cancer Research
Subjects:
Breast organoid
BRCA1
Progesterone receptor
TPA
Online Access:http://link.springer.com/article/10.1186/s13058-019-1214-0

Internet

http://link.springer.com/article/10.1186/s13058-019-1214-0

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