MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders

MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders

Abstract Background RASopathies are a group of disorders that result from mutations in genes coding for proteins involved in regulating the Ras-MAPK signaling pathway, and have an increased incidence of autism spectrum disorder (ASD). Legius syndrome is a rare RASopathy caused by loss-of-function mu...

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Main Authors: Sarah C. Borrie, Ellen Plasschaert, Zsuzsanna Callaerts-Vegh, Akihiko Yoshimura, Rudi D’Hooge, Ype Elgersma, Steven A. Kushner, Eric Legius, Hilde Brems
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Autism
Subjects:
RASopathy
Autism spectrum disorder
Spred1
Neurofibromatosis type 1
Social dominance
Ultrasonic vocalization
Online Access:https://doi.org/10.1186/s13229-021-00458-2

Internet

https://doi.org/10.1186/s13229-021-00458-2

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